Mechanisms of spinal cord stimulation in ischemia

Mechanisms of spinal cord stimulation in neuropathic pain.

The understanding of the mode of action of spinal cord stimulation (SCS) as treatment of neuropathic pain is still fragmentary. SCS evolved from the gate-control theory postulating a spinal modulation of noxious inflow, but there is little evidence that SCS influences nociceptive pain; pain relief in peripheral vascular disease and angina pectoris is presumably secondary to other SCS effects. I...

Mechanisms of Spinal Cord Stimulation in Neuropathic Pain

The effects of electrical stimulation of the body or nervous system have been recognized for thousands of years in every culture. It is said that since circa 9000 BC, bracelets and necklaces of magnetite and amber were used to prevent headaches and arthritis (Schechter, 1971). The ancient Egyptians used electrical discharges of the Nile catfish to treat neuralgia, headaches and other painful di...

O14: Cellular and Molecular Mechanisms of Spinal Cord Trauma

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Spinal Cord Ischemia in Rabbits

Background and Purpose: The lipophilic calcium channel antagonist flunarizine has been demonstrated to be neuroprotective in several models of cerebral ischemia. Ischemic spinal cord injury may have a similar pathophysiology and hence may respond in a similar fashion. This study was designed to investigate the eifects of pretreatment with flunarizine on systemic hemodynamics, spinal cord blood ...

Spinal Cord Stimulation (SCS)